RNA polymerases from low G+C gram-positive bacteria

Title: RNA polymerases from low G+C gram-positive bacteria
Creator: Miller, Michael; Oakley, Aaron J.; Lewis, Peter J.
Relation: Transcription Vol. 12, Issue 4, p. 92-102
Publisher Link: http://dx.doi.org/10.1080/21541264.2021.1964328
Publisher: Taylor & Francis
Resource Type: journal article
Date: 2021
Description: The low G + C Gram-positive bacteria represent some of the most medically and industrially important microorganisms. They are relied on for the production of food and dietary supplements, enzymes and antibiotics, as well as being responsible for the majority of nosocomial infections and serving as a reservoir for antibiotic resistance. Control of gene expression in this group is more highly studied than in any bacteria other than the Gram-negative modelÂ Escherichia coli, yet until recently no structural information on RNA polymerase (RNAP) from this group was available. This review will summarize recent reports on the high-resolution structure of RNAP from the model low G + C representativeÂ Bacillus subtilis, including the role of auxiliary subunits δ and ε, and outline approaches for the development of antimicrobials to target RNAP from this group.
Subject: RNA polymerase; transcription regulation; low G+C bacteria; auxiliary factors; antibiotics; SDG 7; Sustainable Development Goals
Identifier: http://hdl.handle.net/1959.13/1485774
Identifier: uon:51689
Identifier: ISSN:2154-1264
Language: eng
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